Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis
Experimental & Molecular Medicine
;
: 550-557, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-84647
ABSTRACT
We have previously shown that the inhibition of fibroblast growth factor (FGF) signaling induced endodermal gene expression in the animal cap and caused the expansion of the endodermal mass in Xenopus embryos. However, we still do not know whether or not the alteration of FGF signaling controls embryonic cell fate, or when FGF signal blocking is required for endoderm formation in Xenopus. Here, we show that FGF signal blocking in embryonic cells causes their descendants to move into the endodermal region and to express endodermal genes. It is also interesting that blocking FGF signaling between fertilization and embryonic stage 10.5 promotes endoderm formation, but persistent FGF signaling blocking after stage 10.5 restricts endoderm formation and differentiation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pirróis
/
Xenopus laevis
/
Transdução de Sinais
/
Receptores de Fatores de Crescimento de Fibroblastos
/
Hibridização In Situ
/
Regulação da Expressão Gênica no Desenvolvimento
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Proteínas de Xenopus
/
Endoderma
/
Fatores de Crescimento de Fibroblastos
Limite:
Animais
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2008
Tipo de documento:
Artigo
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