Effects of polysaccharides from Scrophulariae Radix on glucolipid metabolism and hepatic insulin signaling pathway in type 2 diabetic rats / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 1586-1592, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-846531
ABSTRACT
Objective:
To explore effects of polysaccharides from Scrophulariae Radix (PFR) on glucolipid metabolism and hepatic insulin signaling pathway in type 2 diabetic rats.Methods:
Diabetic rat models were constructed by STZ injection, and randomly divided into five groups model group, low, medium and high dose groups (80, 160, 320 mg/kg) of PFR, and positive drug group of metformin (200 mg/kg); In addition, ordinary feed rats of the same age were set as normal group; Body weight and survival status, fasting blood glucose (FBG), blood lipid (TC, TG, HDL-C, LDL-C), liver function (ALT, AST), renal function (CREA, BUN), glycosylated hemoglobin (GHb), insulin secretion (FINS), C-peptide, SOD, MDA, CAT, GSH-Px, and other indicators were detected after drug delivery for six weeks; HE staining and oil red O staining were used to evaluate the pathological changes and steatosis of liver in rats; Western blotting was used to detect the changes of hepatic insulin signaling pathway related protein.Results:
PFR increased the weight of diabetic rats, improved the metabolic function, reducde the content of FBG, GHb, ALT, AST, CREA, BUN, TC, TG, LDL-C, MDA and increased the content of HDL-C, FINS, C-peptide, SOD, CAT and GSH-Px; Western blotting assay showed that PFR could activate IRS-2/PI3K/Akt signaling pathway and increase the protein levels of PPAR-γ and GLUT-4.Conclusion:
PFR could improve glucolipid metabolism in type 2 diabetic rats by regulating the hepatic insulin signaling pathway.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2020
Tipo de documento:
Artigo
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