X-linked Toll-like receptor 7 polymorphism associated with susceptibility to Chikungunya Fever
Asian Pacific Journal of Tropical Medicine
;
(12): 137-141, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-846892
ABSTRACT
Objective:
To investigate the association between TLR3 and TLR7 polymorphisms with susceptibility and clinical manifestations of Chikungunya Fever.Methods:
A total of 177 individuals were studied 73 patients with a confirmed diagnosis for Chikungunya virus and 104 non-infected individuals. Polymorphisms were determined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).Results:
Our analysis showed an increased CC genotype frequency of the TLR7 rs3853839 polymorphism in male patients compared to control (29% versus 2%, respectively; OR=20.69; 95 % CI= 2.55-167.36; P<0.001). Furthermore, arthritis (acute and chronic) was frequently found in CC male patients. On the contrary, 65% of CG carriers were no-infected males (29% versus 65%, respectively; OR=0.23, 95% CI=0.48-3.04; P=0.002). Finally, we observed a higher frequency of lymphopenia in CG male patients (CG=666.86±233.77, GG=1,314.27±752.29 cells/mm3, P=0.047).Conclusions:
Our results suggest the TLR7 rs3853839 polymorphism is associated with lymphopenia and increased susceptibility to Chikungunya Fever in males.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Asian Pacific Journal of Tropical Medicine
Ano de publicação:
2019
Tipo de documento:
Artigo
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