Photoreceptor cell replacement therapy for retinal degeneration diseases / 中国组织工程研究

ABSTRACT

BACKGROUND: There is no effective treatment for retinal degenerative diseases, among which the loss of photoreceptor cells, dysfunction and loss of photoreceptor cells are the main causes of retinal degenerative diseases. Photoreceptor cell transplantation as a promising cell replacement therapy is the main research direction today. OBJECTIVE: To review the progress of photoreceptor cell replacement in the treatment of retinal degeneration. METHODS: PubMed, CNKI and Wanfang databases were searched. The Chinese keywords were “photoreceptor cells, retina, transplantation” and the English keywords were “photoreceptors, retina, transplantation”. After preliminary screening by reading the titles and abstracts, the articles with low relevance to the subject were excluded, and a total of 62 articles were finally included for review. RESULTS AND CONCLUSION: The transplantation of exogenous cells into the retinal degeneration environment to replace the photoreceptors lost in advanced retinal degeneration has shown great advantages and provided a new therapeutic strategy for the diseases of retinal degeneration. However, standardized cell screening protocols for clinical use are still not perfect, which is an important challenge for future research.