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Genome-wide identification, classification and phylogenetic analysis of fasciclin gene family for osteoblast specific factor 2 / 中国组织工程研究
Chinese Journal of Tissue Engineering Research ; (53): 1243-1248, 2021.
Artigo em Chinês | WPRIM | ID: wpr-847140
ABSTRACT

BACKGROUND:

There is no systematical report on the conserved structure, protein characteristics and phylogenetic relationship of the Fasciclin gene family.

OBJECTIVE:

To investigate the evolutionary history of the Fasciclin gene family, and to systematically analyze the conservative structure, protein characteristics, and phylogenetic relationships of this gene family

METHODS:

Based on the published genome data of eight species such as people, chimpanzee and zebrafish, HMM models were established using the HMMER software to analyze the characteristics and genetic structure, structure domain and biochemical characteristics, evolutionary relationships and expression characteristics of the Fasciclin gene family. RESULTS AND

CONCLUSION:

In the eight species of fish (zebrafish), amphibian (xenopus), bird (chicken), reptile (Trionyx sinensis), mammal (rat, mouse) and primate (chimpanzee, human), 5, 5, 4, 5, 5, 4, 4, and 4 fasciclin candidate genes were retrieved respectively. Through the phylogenetic analysis of the fasciclin gene in these eight species, the evolutionary tree of fasciclin gene families can be divided into four evolution branch. The two branches of all are more conservative, likely to be the main osteoblast specific factor; the third branch may be osteoblast specific factor of amphibians, mammals and primate; and the final branch also has a good conservative, but the Xenopus and mouse in the branch has two copies of the genes, and this branch may play an important role in the evolution of these two species. Overall, in the evolution of species, the gene family has no larger changes, and such genes may be important for the growth and development. The lack of such genes may lead to the death of the individual or the extinction of species.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Tissue Engineering Research Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Tissue Engineering Research Ano de publicação: 2021 Tipo de documento: Artigo