Application of alginate based hydrogels/dressings in wound healing: Sustained, dynamic and sequential release / 中国组织工程研究

ABSTRACT

BACKGROUND: Alginate can improve the hydrophilic quality of wound dressing, create moist wound microenvironment, and remove wound exudate. Currently, alginate bimolecular materials have been used in the design and development of various wound dressings to improve the efficiency of wound healing. OBJECTIVE: To summarize the research and progress of alginate based hydrogels/dressings in skin wound healing. METHODS: We searched PubMed, Science Direct and CNKI databases from 2000 to 2020 with the English terms of “alginate hydrogel, wound healing, wound dressing, mesenchymal stem cell, growth factor, nanoparticles, diabetic wound, antibiotics, bioactive peptide, three-dimensional printing” and the Chinese terms of “alginate, wound healing”. Based on the inclusion and exclusion criteria, 60 articles were finally reserved for review. RESULTS AND CONCLUSION: (1) The cross-linking of alginate with other organic or inorganic materials can improve the mechanical properties and biodegradability of composite materials, and create a moist and mild wound microenvironment. (2) Alginate based hydrogel/dressing can be used as a delivery platform to load seed cells, growth factors or other bioactive substances to speed up wound healing. (3) It still need to be further explored by researchers to make alginate materials have better cell recognition sites, improve the mechanical properties of composite scaffold materials, control the microstructure of alginate biomaterials and control the dynamic, sustained and sequential release of drugs or cells.