Effects of verapamil in cardioplegic perfusates on the ischemic myocardium in isolated rat heart / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 119-124, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-84724
ABSTRACT
Using isolated rat heart preparations, we observed the protective effects of verapamil cardioplegia on ischemic myocardial injury. Isolated rat hearts were subjected to global ischemia at 25degrees C. Twenty four isolated Sprague Dawley rat hearts underwent 30 minutes of the retrograde nonworking perfusion with Krebs-Henseleit buffer solution followed by 25degrees C cardioplegic solution(St. Thomas' Hospital Cardioplegic Solution) for 60 minutes. Before ischemic arrest, rat hearts were treated with cold cardioplegic solution in control group(n=12) and cold cardioplegic solution with verapamil(1mg/L) in experimental group(n=12). After 60 minutes of ischemia, hemodynamic and biochemical parameters such as heart rate, left ventricular pressure(LVP), +dp/dt max, coronary flow and creatine phosphokinase(CPK) were measured before giving cardioplegia and 30 minutes after reperfusion. Verapamil group exhibited greater recovery of heart rate, LVP, +dp/dt max, coronary flow and CPK than control group(p<0.05).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Perfusão
/
Soluções Cardioplégicas
/
Verapamil
/
Reperfusão
/
Creatina
/
Coração
/
Parada Cardíaca Induzida
/
Frequência Cardíaca
/
Hemodinâmica
/
Isquemia
Limite:
Animais
Idioma:
Coreano
Revista:
The Korean Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
1997
Tipo de documento:
Artigo
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