Semantic memory impairment and neuroregulation in patients with mild cognitive impairment / 中国组织工程研究

ABSTRACT

BACKGROUND: Alzheimer’s disease is a progressive neurological degenerative disease characterized by cognitive decline. Cognitive decline can make the elderly gradually losing their self-care ability, which eventually affects daily life and activities. Mild cognitive impairment is a precursor state of Alzheimer’s disease, and to diagnose and treat mild cognitive impairment as soon as possible has great significance in preventing the development of Alzheimer’s disease. OBJECTIVE: To summarize the development and future prospects of the assessment and treatment of semantic memory disorders due to mild cognitive impairment. METHODS: A computer-based retrieval of PubMed, Web of Science, CNKI, and WanFang was performed for related studies on the evaluation and treatment of mild cognitive impairment in semantic memory. The keywords were “mild cognitive impairment, semantic memory impairment, semantic memory deficit” in English and Chinese, respectively. The retrieval time was from January 2009 to November 2019. RESULTS AND CONCLUSION: Semantic memory disorder is one of the main clinical symptoms of mild cognitive impairment, and has certain specificity. At present, there are different types of memory scales that can be used as neurophysiological measures of semantic memory disorder due to mild cognitive impairment. The temporal lobe, frontal lobe, and premotor region may participate in the semantic memory loop. Targeted semantic memory neurophysiology and auxiliary examinations, and targeted semantic memory rehabilitation training can be helpful for early identification of the occurrence and transformation of mild cognitive impairment.