A drug-loading system for electrospinning wound repair: Component selection and construction strategy / 中国组织工程研究

ABSTRACT

BACKGROUND: As an excellent material in recent years, electrospinning membrane provides a new method to promote the healing of wound. Based on the diversity of its fibrous base and active components, it is flexible to build a drug delivery system for electrospinning wound repair. OBJECTIVE: To summarize the mechanism and functional characteristics of the components belonging to electrospinning fiber membrane drug-loading system, and to guide the selection of construction strategies for wound healing materials. METHODS: The literature search was performed in Web of Science, PubMed, CNKI, and WanFang databases. The key words were “electrospinning, wound dressing, nanofibers, wound healing, drug deliver”. Ninety articles were included in this review finally. RESULTS AND CONCLUSION: The construction strategies of electrospinning wound repair drug-delivery system were diverse. Through electrospinning technology, different polymers could be used to carry stem cell components or other small functional bioactive “drugs”, thus constructing a variety of effective composite systems. These materials might be applied to all aspects of the wound healing process, and finally achieve the purpose of promoting wound soft tissue healing. The excellent drug-loading system/drug-loading strategies have expanded the vision of wound treatment. Compared with traditional hydrogel and accessory treatment products, the multi-mechanism, function and possibility characteristics of electrospinning wound repair drug-delivery system determined its advantages in wound treatment.