Advantages and problems of induced membrane technology in the treatment of infectious nonunion / 中国组织工程研究

ABSTRACT

BACKGROUND: The course of infectious bone nonunion is often difficult to heal and has a high risk of recurrence, which brings great trouble to patients’ lives. With the continuous research on the induced membrane technique, the advantages of the treatment of infectious nonunion with the induced membrane technique have gradually emerged and become a new research direction of medical work. OBJECTIVE: To explore the action mechanism of induced membrane technology in the treatment of infectious nonunion. METHODS: The relevant domestic and foreign literatures from 2013 to 2019 of PubMed, MEDLINE, Wanfang, CNKI, VIP, and Ubiquitous Chinese Biomedical Literature Database were retrieved. The key words were “induced membrane technique, infectious nonunion, induced membrane, growth factor” in Chinese and English. RESULTS AND CONCLUSION: The biological structure and function of the induced membrane are similar to that of the periosteum. It can induce the formation of osteoblasts and promote the growth of bone tissue. The induced membrane can secrete many kinds of growth factors, such as vascular endothelial growth factor, bone morphogenetic protein 2 and transforming growth factor β1. The application of induced membrane technology in clinic, especially in the field of fracture, has achieved remarkable results, which provides a new choice for the treatment of infectious nonunion. Exploring the most suitable stuffing material and bone grafting time and the dynamic ratio of the two have become the breakthrough point and challenge of this technology.