The clinical application of platelet-rich plasma to repair chronic refractory wounds: A retrospective study and literature retrieval evidence analysis / 中国组织工程研究

ABSTRACT

BACKGROUND: Autologous platelet-rich plasma (PRP) has a certain repair effect on refractory wounds, which can accelerate the healing of soft tissue. The PRP gel can prevent the loss of platelets, make platelets survive for a long time and secrete growth factors, which is conducive to wound healing. OBJECTIVE: To observe the effects of PRP on the healing of chronic refractory wounds and analyze the research status. METHODS: Twenty-two patients with refractory wounds, including eight cases of diabetic ulcer, three cases of traumatic ulcer, three cases of traumatic bone ununion, two cases of bone exposure after electric burn, and six cases of radiation ulcer, were treated with PRP gel after surgical debridement. Dressing and PRP gel were regularly changed, and wound healing was observed. The first author retrieved WanFang for the literature addressing the treatment of chronic refractory wounds with autologous PRP gel published in recent 10 years, and analyzed the research status. RESULTS AND CONCLUSION: (1) In all of chronic wounds (22 cases), complete healing was observed In 11 cases as well as in 5 cases after skin flap transfer, and the remaining 6 cases were subjected to skin grafting. There was no disease transmission or immune rejection. The results indicate that the use of PRP gel is a safe and effective method for chronic refractory wounds. (2) Thirty-two relevant literatures were enrolled in literature retrieval. Although the number of relevant articles published from 2016 to 2018 increased yearly, there is no convincing evidence for autologous PRP in the treatment of chronic refractory wounds. There is lack of large-scale, multicenter, prospective, randomized controlled studies. How to standardize PRP preparation and use to ensure a curative effect with high stability remains to be elucidated.