Advances in targeted mitochondria inhibiting cancer stem cells / 肿瘤

ABSTRACT

Cancer stem cells (CSCs) have long been considered as the origin of tumorigenesis, recurrence and metastasis. The changes of mitochondrial structure and morphology, abnormal activation of signaling pathways, mitochondrial dysfunction, reactive oxygen species (ROS) and mitochondrial autophagy in CSCs are the key factors to maintain the stem cell nature of CSCs and to regulate the proliferation and apoptosis of CSCs, and are also the major cause of anticancer treatment failure. This review particularly elucidates the mechanisms of mitochondria in CSCs affecting apoptosis, signaling pathway, energy metabolism, ROS and mitochondrial autophagy, in order to provide a powerful basis for the potential anti-tumor therapy targeting mitochondria in CSCs.