Progress in AT-motif binding factor 1 gene and malignant tumors / 肿瘤

ABSTRACT

AT-motif binding factor 1 (ATBF1), also named as zinc finger homeobox 3 (ZFHX3), is reported as a transcriptional regulator with the highest molecular weight. ATBF1 regulates mRNA transcription by binding to AT-rich motif of gene promoter. In recent years, more and more studies have shown that ATBF 1 gene is an important candidate tumor suppressor gene. Frequent mutations and loss of heterozygosity (LOH) are found in ATBF 1 gene in multiple tumors, including prostate cancer, gastric cancer, breast cancer, cervical cancer and colorectal cancer. The gene expression and protein localization of ATBF1 are associated with the clinical diagnosis and treatment of tumors. Moreover, ATBF1 plays an essential role in multiple signaling pathways to regulate cell proliferation, differentiation and apoptosis. This review summarizes the research progress of ATBF 1 gene in malignant tumors from four aspects DNA, mRNA, protein and molecular mechanism, in order to comprehesively understand the anti-cancer mechanism of ATBF1 and its clinical significance in diagnosis and treatment of tumors.