Efficacy of olanzapine in treatment of chemotherapy-induced nausea and vomiting and its advances in related clinical research / 肿瘤

ABSTRACT

In spite of the serious effects on the patient's quality of life, the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) remains a trouble problem. With the development of new agents, the acute and delayed CINV have been significantly improved in response rate, however the controlling of nausea and breakthrough CINV are undesirable. Recently, olanzapine has been demonstrated effectively in the prevention and treatment of CINV, especially in nausea, that can improve the quality life of patients as well. The paper sketches the mechanism of CINV and mainly summarizes the progress in prevention and treatment of olanzapine in CINV.