Progress in the molecular relationship between zinc deficiency and esophageal cancer / 肿瘤

ABSTRACT

Esophageal cancer is a common gastrointestinal malignancy and China has a high incidence of esophageal cancer. Zinc deficiency is a key risk factor for the occurrence and development of esophageal cancer and affects its progression through various ways, including changing the expression of coding genes and non-coding genes. In addition, the lack of zinc ions can also affect the stability of zinc finger protein (ZNF). The dysregulation of ZNF and its associated long non-coding RNAs (LncRNAs) play an important role in the progression of esophageal cancer. This paper summarizes the molecular relationship between zinc deficiency and esophageal cancer, hoping to provide new strategies and methods for the early diagnosis, targeted therapies and prognosis assessment of esophageal cancer.