Progress in CD26/DPPIV and tumor / 肿瘤

ABSTRACT

Dipeptidyl peptidase IVW (DDPIVW), also known as CD26, is a protease with a variety of biological functions, which is involved in signal transduction and activation of immune cells. The abnormal expression and activation of CD26 are closely related to the occurrence and development of many diseases. In some tumors, the expression level of CD26 decreases with the disease progression, suggesting that CD26 is a tumor suppressor. On the other hand, CD26 has also been described as a protein related to the invasion of malignant tumor, involved in the regulation of cell malignant phenotypes such as proliferation, migration and adhesion, as well as the related pathological processes, so CD26 is considered to be a marker of malignant tumor and cancer stem cells. Therefore, CD26 is closely associated with the occurrence, development, diagnosis and treatment of tumors. In this article, the research progress in CD26 and the relevant tumors in recent years is reviewed to provide the theoretical basis for the application of CD26 in clinical diagnosis, treatment and prognosis evaluation of tumors.