Application of endocrine therapy combined with paclitaxel (albumin bound) in patients with intermediate and advanced prostate cancer / 肿瘤

ABSTRACT

Objective: To observe the efficacy of icalutamide and goserelincombined with paclitaxel (albumin bound) and prednisone in patientswith intermediate and advanced prostate cancer.Methods: One hundred patients with intermediate and advancedprostate cancer were randomly divided into control group (n = 50)and observation group (n = 50). The patients in the control groupwere treated with oral bicalutamide and goserelin acetate sustainedrelease.The patients in the observation group were treated with oral bicalutamide, goserelin acetate sustained-release, paclitaxel (albumin bound) andprednisone. After 3 cycles of treatment, the effects and adverse reactions were compared.Results: The complete remission rate and the partial remission rate of the observationgroup were higher than those in the control group (22.0% vs 8%, 60% vs 40%, both P 0.05).Conclusion: The endocrine therapy combined with paclitaxel (albumin bound) and prednisonein patients with intermediate and advanced prostate cancer can achieve good efficacy.