Thiotepa-based autologous stem-cell transplant for primary central nervous system lymphoma / 肿瘤

ABSTRACT

Objective: To explore the induction chemotherapy and consolidation therapy for primary central nervous system lymphoma (PCNSL), and in order to improve the clinical understanding of this type of lymphoma, and to provide experiences in systemic therapy. Methods: A case of diffuse large B-cell PCNSL was reported. The clinical features, diagnosis and the treatment were reviewed, and the relevant literatures were reviewed and discussed. Results: The patient with diffuse large B-cell PCNSL was treated with high-dose methotrexate-based induction chemotherapy, then sequentially received two courses of high-dose chemotherapy (HDC) with thiotepa/autologous stem cell transplant (ASCT), and achieved significant clinical efficacy with sustained remission after transplantation. Conclusion: PCNSLis a group of uncommon primary brain tumors. Thiotepa-based HDC/ASCT as consolidation therapy may play an important role in improvement of prognosis, especially for young patients.