Progress in survival regulatory mechanism of circulating tumor cells and their targeted therapeutic strategies / 肿瘤

ABSTRACT

Circulating tumor cells (CTCs) are a kind of tumor cells disseminated in the peripheral blood circulation due to spontaneous operation, diagnosis or treatment. CTCs have been regarded as crucial source of tumor recurrence and metastasis. The recent studies show that CTCs can survive in circulatory system through overcoming mechanical damage of blood shear stress, evading immune destruction, and resistance to anoikis and systemic chemotherapy drugs. In this paper, the possible survival mechanisms involved in CTCs formation and migration are reviewed according to their biological characteristics and blood microenvironment, while the latest progress in the novel strategies for tumor treatment targeting CTCs is discussed.