Photodynamic diagnosis and white light imaging in treatment of nonmuscle-invasive bladder cancer: A meta-analysis / 肿瘤

ABSTRACT

Objective: To compare the efficacy of photodynamic diagnosisassisted transurethral resection of bladder tumor (TURB) with conventional white light imaging-assisted TURB in primary nonmuscle- invasive bladder cancer. Methods: Cochrance Libarary, PubMed, Embase, Wanfang Data, VIP Data and Chinese BioMedical Literature Database (CBM). The endpoints were 3-month, 9-month, 1-year, 2-year and 5-year biochemical failure rates. After evaluating the quality of the included literatures and extracting the data, the Metaanalysis was performed using Review Manager 5.3 software. The results were expressed as risk ratio (RR) with the corresponding 95% confidence interval (CI). Results: The final analysis included ten studies including 2 430 patients. The 9-month (RR 0.80,95% CI 0.69-0.93; P = 0.005), 1-year (RR 0.65, 95% CI 0.46-0.91; P = 0.010), 2-year (RR 0.54, 95% CI 0.40-0.72; P < 0.001) and 5-year (RR 0.76, 95% CI 0.61-0.94; P = 0.010) biochemical failure rates were lower in patients who received photodynamic diagnosisassisted TURB. Conclusion: The efficacy of photodynamic diagnosis-assisted TURB is superior to conventional white light imaging-assisted in efficacy of primary non-muscle-invasive bladder cancer in 5 years.