The relationship between EGFR gene mutation and the expressions of ERCC1 and RRM1 proteins in stages I-III lung adenocarcinoma tissues / 肿瘤
Tumor
;
(12): 258-263, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-848910
ABSTRACT
Objective:
To investigate the relationship between the mutation of EGFR (epidermal growth factor receptor) gene and the expressions of ERCC1 (excision repair cross-complementation group 1) and RRM1 (ribonucleotide reductase M1) proteins in adenocarcinoma tissues from patients with stages I-III lung adenocarcinoma.Methods:
The status of EGFR gene mutation in exons 19 and 21 in adenocarcinoma tissues from 99 patients with stages I-III lung adenocarcinoma was detected by amplification refractory mutation system using fluorescence-based quantitative-PCR instrument. The expressions of ERCC1 and RRM1 proteins were detected by immunohistochemistry.Results:
The mutation rate of EGFR gene in all patients was 46.5%. The females or the non-smokers had a higher mutation rate of EGFR gene (P 0.05). There was also no relationship between the expressions of ERCC1 and RRM1 proteins (P > 0.05).Conclusion:
A low level of ERCC1 protein is more likely to be expressed in lung adenocarcinoma patients with EGFR mutation, who may benefit from the platinumbased chemotherapy. Copyright © 2013 by TUMOR.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Tumor
Ano de publicação:
2013
Tipo de documento:
Artigo
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