Progress in research on cyclophilin A and malignant tumors / 肿瘤

ABSTRACT

CypA (cyclophilin A), the main intracellular receptor of immunosuppressant CsA (cyclosporin A), is the first discovered and most abundant one in cyclophilin family and has been studied in-depth. CypA has PPIase (peptidyl-prolyl cis-trans isomerase) activity and molecular chaperone functions which enable it playing a role in correct protein folding. CypA also involves in a variety of biological functions such as immune suppression, inflammatory response, and oxidative stress response. Recent studies have found that CypA was overexpressed in many malignant tumors, and it can promote the proliferation of tumor cells, inhibit apoptosis, and mediate tumor invasion and metastasis. It may become a new diagnostic and therapeutic target of some malignant tumors in future. Copyright © 2013 by TUMOR.