Influence of brown adipose tissue activity on 18F-FDG uptake in tumors / 肿瘤

ABSTRACT

Objective: To evaluate the influence of BAT (brown adipose tissue) activity on 18F-FDG (18F-fluoro-2-deoxyglucose) uptake in tumors in cancer-bearing mice by using PET/CT (positron emission tomography/computed tomography) imaging. Methods: The model of mice bearing NCI-H1299 human non-small cell lung cancer was established. The activity of BAT in mice was adjusted through regulating the experimental conditions. Two groups were designed in this study, including BAT-activation group (the activity of BAT in mice was stimulated by cold exposure and food diet during the period of 18F-FDG uptake) and BAT-inhibition group (the activity of BAT in mice was inhibited by fasting, anesthesia and heating). The mice were scanned with micro-PET/CT and the uptake of 18F-FDG in tumors in the two groups was analyzed and compared. The SUV (standard uptake value) was calculated. Results: The tumor in BAT-activation group was nearly invisible on PET image and its 18F-FDG uptake value (SUV 0.15±0.06) was significantly lower than that in the BAT-inhibition group (SUV 0.58±0.20) (P < 0.05). Conclusion: The enhancement of BAT activity will significantly decrease the uptake of 18F-FDG in tumors and influence the imaging of the tumors. Copyright © 2013 by TUMOR.