Risk factors for pancreatic cancer: A case-control study / 肿瘤

ABSTRACT

Objective: To investigate the risk factors for pancreatic cancer. Methods: The clinicaldata including gender, age, hypertension, smoking, family history of cancer, gastrointestinal surgery,biliary disease, chronic pancreatitis, serum total cholesterol level, serum triglyceride level, hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (anti-HCV) and diabetes mellitus from 290 patientswith pancreatic cancer and 312 controls without cancer and metabolic diseases between June 2000 andJune 2010 were retrospectively analyzed. The univariate and multivariate analyses were performed to determine the risk factors for pancreatic cancer. Results: The univariate analysis indicated that diabetes mellitus, hypertension, smoking, family histroy of cancer, gastrointestinal surgery, biliary disease, chronic pancreatitis, serum total cholesterol level and serum triglyceride level were different between the twogroups (P <0.05). The multivariate analysis revealed that smoking [odds ratio (OR )= 1.66, 95% confidence interval (CI )= 1.08-2.56], diabetes mellitus (OR= 11.14, 95%CI= 5.07-24.49), hypertension (OR= 1.64, 95%CI= 1.07-2.51), biliary disease (OR= 4.19, 95%CI= 2.74-6.40) and serum triglyceride level (OR= 1.83, 95%CI= 1.44-2.32) were independent risk factors for pancreatic cancer (P <0.05). Conclusion: Smoking, diabetes mellitus, hypertension, biliary disease and serum triglyceride level may be independent risk factors for pancreatic cancer. Copyright© 2011 by TUMOR.