The expressions of integrin alpha 3 and MMP-9 in pancreatic adenocarcinoma and their association with clinical pathological characteristics / 肿瘤

ABSTRACT

Objective: To detect the expressions of integrin alpha 3 and matrix metalloproteinase-9 (MMP-9) in pancreatic adenocarcinoma, and investigate their relationahip with clinicopathological parameters, furthermore analyze the correlation between integrin alpha 3 and MMP-9. Methods: We collected 100 cases of paraffin-embedded pancreatic adenocarcinoma tissues. The expressions of integrin alpha3 and MMP-9 were detected by immunohistochemical labelled streptavidin biotin ( LsAB) methods. Results: Ninety eight percent pancreatic adenocarcinomas were integrin alpha3-positive and 75% pancreatic adenocarcinomas highly expressed integrin alpha 3. The expressions of integrin alpha 3 in head, neck and uncinate pancreatic adenocarcinomas were stronger than those in pancreatic adenocarcinomas located at body and tail (P=0.041). Increased expression of integrin alpha3 was associated with local lymph node metastasis (P=0.012). Eighty one percent pancreatic adenocarcinomas expressed MMP-9 and 39% of them showed strongly positive. There was no correlation between the expression of MMP-9 and age, gender, tumor location, tumor grade, duodenum invasion, local lymph node metastasis, perineural invasion or TNM stage. The expression of MMP-9 positively correlated with the expression of integrin alpha 3. Conclusion: Expression of integrin alpha 3 correlates with the location of pancreatic adenocarcinomas and plays a role in local lymph node metastasis. Integrin alpha 3 might up-regulate the expression of MMP-9.