Surgical procedure and prognotic analysis of extrahepatic cholangiocarcinoma: A report of 161 cases / 肿瘤

ABSTRACT

Objective: To explore the impact of clinical features and surgical procedure on survival of extrahepatic cholangiocarcinoma (EHCC) and the prognostic factors in patients with EHCC after curative resection. Methods: From 1995 to 2006, 161 EHCC patients undergoing operations were included in this study. The clinical features, diagnosis, surgical procedure and follow-up data were retrospectively analyzed. Factors influencing postoperative survival were analyzed using COX multiple stepwise regression model. Results: Of the 161 patients, 110 underwent radical resection and 32 underwent palliative resection, 19 underwent drainage or laparotomy. The overall 1-, 2-, 3-,and 5-year survival rates were 74.9%, 45.3%, 36.5%, and 11.1%, respectively. COX analysis showed hepatic infiltration, portal vein and/or hepatic artery invasion, and lymph node metastasis were independent prognostic factors after radical resection (P < 0.05). Conclusion: The radical resection is the key factor for increasing the long-term survival rate and improving the life qualities of EHCC patients. Partial hepatectomy or/and pancreatoduodenectomy in combination with skeletonization may be helpful for increasing radical resection rate and long-term efficacy.