The pathologic and clinic characteristics of papillary urothelial neoplasm with low malignant potential / 肿瘤

ABSTRACT

Objective: To discuss the pathologic and clinical characteristics of papillary urothelial neoplasm with low malignant potential (PUNLMP). Methods: We retrospectively analyzed 41 cases of PUNLMP confirmed by pathological examination from 2003 to 2006 and selected 28 cases of urothelial papilloma and 51 cases of low-grade papillary urothelial carcinoma as control. Results: Forty one cases of PUNLMP (male 31; female 10, ranging from 33 to 87 years, average 61.6 years) were recruited in this study. Recurrence occurred in 6 cases (15%) with the mean recurrence period of 24.6 months. No progression was detected by pathological examination. Four patients had multiple tumors, among them 2 (50%) cases recurred. In 28 cases of urothelial papilloma, recurrence was observed in 1 (4%) case with no progression. In 51 cases of low-grade papillary urothelial carcinoma, 18 (35%) cases experienced recurrence and 5 cases (10%) had progressed disease. The difference in recurrence rate among the three groups was significant (P = 0.002). Conclusion: PUNLMP has its own pathologic and clinical characteristics. The term "low maligant potential" is more appropriate than "carcinoma". Long-term follow-up is needed after surgery because of high recurrence rate.