Clinicopathological and immunohistochemical features of 24 cases of gastrointestinal stromal tumor / 肿瘤

ABSTRACT

Objective: To explore the clinicopathological and immunohistochemical characteristics of gastrointestinal stromal tumor(GIST). Methods: The clinical and pathological features of 24 cases of GIST were observed. The protein expression of CD117, CD34, SMA, and S-100, desmin, and Vimentin were detected by using En Vision Immunohistochemical method. Results: The 24 patients with GIST had an average age of 52.7 years old. They were common in the stomach. The most common presenting signs and symptoms included abdominal pain and GI bleeding. The tumor diameters ranged from 0.6 to 12 cm (mean 4.1 cm). Microscopically, most GIST were composed of spindle cells(14 cases, 59.3%), epithelioid cells (4 cases, 16.6%), or mixed cells(6 cases, 25.0%). The GIST were generally benign in 5 cases (20.8%), borderline in 5 cases (20.8%), and malignant in 14 cases (58.4%). In terms of immunophenotypes, about 23 GIST patients (95.8%) expressed CD117 antigen and 20 patients (83.3%) expressed CD34 antigen. They showed diffuse strong positivities. Conclusion: GIST has a peak incidence in the elderly persons. GIST often occurred in the stomach. The tumors were mainly composed of spindle cells. Most GIST were malignant and borderline. Immunohistochemical detection of CD117 and CD34 antigens is necessary for differential diagnosis.