Advances in animal models of diet-related nonalcoholic fatty liver disease / 解放军医学杂志

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver disease in the world. The environment and the susceptibility of the host genetic background determine the disease phenotype and affect its progress. Dietary factors play an extremely important role in the occurrence and development of metabolic diseases. The food carries energy and information, which directly or indirectly affects the metabolism and function of the human body. Currently animal models of diet-related NAFLD have been very mature, but it is not perfect. Therefore, based on the complexity of NAFLD, in order to elucidate the pathogenesis of disease, look for potential therapeutic targets, evaluate the treatment, it is necessary to develop effectively and safely preclinical models in vitro and in vivo. We should focus on finding pathogenic animal models that are more consistent with human dietary patterns, which is important for further understanding of NAFLD disease. Therefor, this article reviews the current research progress of animal models of diet-related NAFLD, and discuss the importance of establishing new diet-related NAFLD models.