Research advance of PPARγ molecular and gene polymorphism / 解放军医学杂志
Medical Journal of Chinese People's Liberation Army
;
(12): 796-800, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-849794
ABSTRACT
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent nuclear transcription factor, which belongs to the type II nuclear hormone receptor superfamily. Ligand-activated PPARγ is involved in a variety of physiological and pathological processes such as the regulation of immune inflammation, lipid metabolism and glucose homeostasis. In recent years, it has been found that PPARγ gene polymorphism is closely related to the risk of infectious diseases, autoimmune diseases and metabolic diseases, indicating that PPARγ and its gene polymorphism may become potential diagnostic and therapeutic targets for many diseases. In present paper, the research progress of molecular structure, activity regulation, regulatory mechanism of immune inflammation and gene polymorphism of PPARγ are reviewed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Medical Journal of Chinese People's Liberation Army
Ano de publicação:
2019
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS