The application and prospects of organoid technique in esophageal cancer research / 解放军医学杂志

ABSTRACT

Esophageal cancer is a common gastrointestinal tumor. The morbidity and mortality of esophageal cancer in China were 18.85/100,000 and 14.11/100,000, respectively. China is one of the regions with high incidence and high mortality of esophageal cancer in the world. Among them, esophageal squamous cell carcinoma is more common with difficult of early diagnosis. Therefore, there is a great space for research and exploration of early diagnosis and early treatment. Many factors restrict the research on the developing mechanism, drug discovery and screening as well as individualized treatment of esophageal cancer. The lack of an ideal tumor model is one of the important restrictive factors. Organoid is a novel product of 3D culture technology in vitro with the advantages of maintaining the structure, function, genome and drug sensitivity of in situ tissue, and is an excellent tumor research model with such advantages as easy to be operated, relatively low cost, and can be used in conjunction with other advanced technologies. Therefore, esophageal cancer organoid has gradually gained the attention of the academic world, and is expected to be widely used in the field of esophageal cancer research. The present review focuses on the applications and prospects of organoid in the research of esophageal cancer.