Research progress of SDF-1/CXCR-4 pathway in mesenchymal stem cell homing after myocardial infarction / 解放军医学杂志

ABSTRACT

Mesenchymal stem cells (MSCs), for their potential of differentiation into cardiomyocytes and easy acquisition, have been used in repair of myocardium tissue and improvement of heart functions after myocardial infarction. However, a vexed problem is the low homing rate of MSCs no matter what delivery methods (including intravenous, intracoronary or endocardial delivery) are used. SDF-1/CXCR-4 signal pathway plays an important role in variety of stem cell homing, and has been employed to enhance the function of SDF-1/CXCR-4 signal pathway for improving the efficiency of stem cell homing. The present paper has reviewed the methods used recent years to enhance the function of SDF-1/CXCR-4 signal pathway and the mechanism of the signal pathway in MSCs homing.