Pancreatic duct stenting for prevention of post-ERCP pancreatitis: A meta-analysis / 解放军医学杂志

ABSTRACT

Objective To evaluate the role of pancreatic duct stenting in the prevention of post-endoscopic retrograde cholangio-pancreatography (ERCP) pancreatitis (PEP).Methods The literature and corresponding references of randomized controlled trials (RCT) on pancreatic duct stenting for the prevention of PEP were searched from Cochrane Library (1970 to Aug. 2015), PubMed (1966 to Aug. 2015), EMBASE (1966 to Aug. 2015) and China Biology Medicine disc (1978 to Aug. 2015). Literature screening, data extraction, and methodological quality assessment were individually performed by two researchers.The software RevMan 5.3 of Cochrane Collaboration was used for statistical analysis. Results A total of 23 articles with 2556 patients were included in the present study. The result of Meta analysis showed that compared with the control, pancreatic duct stenting could effectively prevent PEP (RR=0.34, 95%CI 0.27-0.43, P<0.00001) from occurrence and alleviate the severity of PEP (RR=0.18, 95%CI 0.08-0.42, P<0.0001). Conclusion Pancreatic duct stenting may effectively prevent the occurrence and alleviate the severity of PEP.