Treatment of multiple vertebral pathological fractures in multiple myeloma patients by percutaneous vertebroplasty: Analysis of 44 cases / 解放军医学杂志

ABSTRACT

Objective To investigate the clinical efficacy percutaneous vertebroplasty (PVP) for multiple vertebral pathological fracture (MVPF) in multiple myeloma (MM) patients. Methods PVP was performed for MVPF in 44 consecutive patients with MM from 2010 to 2014 in our hospital. All the patients had complete medical records. The clinical data were analyzed retrospectively. Preoperative and postoperative visual analog scale (VAS) scores for pain and ECOG scores were measured and analyzed statistically in all the patients. Then the changes of back pain, locomotor activity and life quality after surgery were compared. Results Technical success was achieved in all the 139 diseased vertebrae. The mean injected amount of PMMA was 3.0ml. The mean value of VAS was 7.8 ± 2.9 preoperatively, and significantly decreased to 4.1 ± 1.6(P<0.0l) 1 day after vertebroplasty, to 2.2 ± 1.6(P<0.0l) 1 week after vertebroplasty, and to 2.6 ± 1.9(P<0.0l) 1 month after vertebroplasty. The mean preoperative ECOG scores was 2.9 ± 0.7. One week after the operation, the mean ECOG scores decreased to 2.2 ± 0.3 (P<0.01). There were significant differences between preoperative and postoperative visual analog scale (VAS) scores and ECOG scores. Conclusion PVP is an effective and safe method for treating symptomatic MM with (MVPF).