Your browser doesn't support javascript.
loading
Specific Immunotherapy in Atopic Dermatitis
Allergy, Asthma & Immunology Research ; : 221-229, 2015.
Artigo em Inglês | WPRIM | ID: wpr-85021
ABSTRACT
Allergen specific immunotherapy (SIT) using house dust mite (HDM) extracts has been performed mainly with patients of asthma and allergic rhinitis. In the meanwhile, there has been a long debate on the efficacy of SIT in atopic dermatitis (AD) with only a few double-blind placebo-controlled trials. However, several randomized controlled trials of SIT in AD revealed significant improvement of clinical symptoms and also, positive result was shown by a following meta-analysis study of these trials. In order to predict and evaluate the treatment outcome, finding a biomarker that can predict treatment responses and treatment end-points is critical but it is very challenging at the same time due to the complexity of causes and mechanisms of AD. Other considerations including standardization of the easiest and safest treatment protocol and optimizing the treatment preparations should be studied as well. This review summarizes the basics of SIT in AD including the brief mechanisms, treatment methods and schedules, and also highlights the clinical efficacy of SIT in AD along with mild, controllable adverse reactions. Immunologic effects and studies of various biomarkers are also introduced and finally, future considerations with upcoming studies on SIT were discussed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Agendamento de Consultas / Asma / Biomarcadores / Rinite / Resultado do Tratamento / Pyroglyphidae / Dermatite Atópica / Imunoterapia Tipo de estudo: Ensaio Clínico Controlado / Guia de Prática Clínica / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Allergy, Asthma & Immunology Research Ano de publicação: 2015 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Agendamento de Consultas / Asma / Biomarcadores / Rinite / Resultado do Tratamento / Pyroglyphidae / Dermatite Atópica / Imunoterapia Tipo de estudo: Ensaio Clínico Controlado / Guia de Prática Clínica / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Allergy, Asthma & Immunology Research Ano de publicação: 2015 Tipo de documento: Artigo