The use of sufentanil combined with propofol for analgesia in patients with acute myocardial infarction / 解放军医学杂志

ABSTRACT

Objective To explore the efficacy of sufentanil and propofol for analgesia in patients with acute myocardial infarction (AMI). Methods According to the random number table, 118 AMI patients were divided into sufentanil group and remifentanil group, with 59 in each group. The initial target effect concentrations of sufentanil and remifentanil were 0.25ng/ml and 2ng/ml respectively, and both of them were combined with propofol, initial target plasma concentration of which was 2μg/ml, with an increase of 0.5μg/ml every 2min till the loss of consciousness. Hemodynamic changes at pre-anesthesia induction (T0), preintubation (T1), immediately after intubation (T2), 2min after intubation (T3), end of operation (T4), and extubation (T5), and anesthetic condition, awakening time, postoperative analgesic effect, and complications were compared between two groups. Results Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were lowered at T0-T2 in both groups, and they gradually rose at T2-T5. HR was lowered at T0-T1, and it rose gradually at T1-T5, but SBP and DBP fluctuation was more obvious in remifentanil group than in sufentanil group, with a significant difference at T1-T5, and a significant difference in HR at T1, T2 and T5 (P0.05). The time for recovery of spontaneous breathing, time for eyeopening, upon calling, time of extubation and orientation recovery time were significantly longer in the sufentanil group than those in the remifentanil group (P0.05). Conclusion As compared with remifentanil, sufentanil combined with propofol is used for analgesia in AMI patients resulting in more stable hemodynamics, better postoperative awakening quality, and fewer complications, thus it is worthy of wider clinical use.