Clinical analysis of pyoderma gangrenosum: A report of 15 cases / 解放军医学杂志

ABSTRACT

Objective To explore the clinical characteristics and treatment strategy for pyoderma gangrenosum (PG). MethodsClinical data of 15 PG patients (from Jan. 1995 to Dec. 2011) in Peking University Third Hospital were retrospectively analyzed, and its clinical characteristics and therapy were studied. ResultsThere were 15 PG patients, including 11(73.3%) males and 4(26.7%) females. In 15 patients, 8(53.3%) had the complication of systemic diseases, the ulcer area was 2.8%(0.5%-7.0%) of total body surface area (TBSA) before treatment and 1.2%(0.6%-2.0%) after treatment, and 7(46.7%) did not have the complication of systemic diseases, the ulcer area was 1.6%(1.0%-3.5%) TBSA before treatment and 0.4%(0.1%-0.9%) after treatment. The differences of ulcer area between patients with and without systemic diseases before and after treatment were both statistically significant (P<0.05). Two of them have the complication of myelodysplastic syndrome, whose ulcer areas were larger than 5% of their whole body areas. One of them has effective response to surgical intervention in his stable stage. Conclusions PG is more common in male, and is prone to have the complication of systemic disease, especially myelodysplastic syndrome, which is often accompanied by large ulcer area. The surgical intervention should be forbidden in its progressive stage. The prognosis is remarkably improved by surgical intervention of local ulcer surface on the basis of systemic treatment when the disease is in its stable period.