Clinical observation on effets of high frequency oscillating ventilation on patients with early acute respiratory distress syndrome / 解放军医学杂志

ABSTRACT

Objective To investigate the effect of high frequency oscillating ventilation (HFOV) on patients with early acute respiratory distress syndrome (ARDS) and its mechanism. Methods Through self controlled study, in 25 patients who met criteria of ARDS, their PaO2/FiO2, Paw, arterial blood pH, PaCO2, Cst, cadiac index (CI), heart rate (HR), central venous pressure (CVP), percentage pulmonary shunt (QS/QT), oxygen index (OI) and incidence rate of ventilator associated lung injury (VALI), ventilator associated pneumonia (VAP) were recorded 1, 3, 5 days before and after HFOV. Results Five days later, X ray examination showed that all of the patients got better. Seven days later, 3 patients died because of original diseases, but their symptoms of ARDS improved. Three days after HFOV treatment, the value of PaO2/FiO2 (172.5±69.8) and Cst (63.4±10.5) increased compared with baseline (95.5±29.5, 31.5±4.5, P0.05). Conclusion HFOV can improve oxygenation index and pulmonary complications of patients with early ARDS.