Investigation and risk factor analysis of hyperuricemia in pilots / 解放军医学杂志

ABSTRACT

Objective To investigate the incidence of hyperuricemia in military pilots and the relationship between hyperuricemia and other related risk factors of cardiovascular diseases. Methods A total of 2563 pilots, who had undergone a regular physical examination in the Air Force General Hospital from 2005 to 2010, participated in the current study. The participants were divided into high serum uric acid (UA) group (hyperuricemia group, UA >420μmol/L, n=294) and normal UA group (n=2269). The incidence rates of hypertension, hyperglycemia, and hyperlipemia were compared between these two groups. The dependent variable was serum UA level of the pilots. Other indices included the total cholesterol (CHO), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), smoking, body weight, and flight time as independent variable. Logistic multivariate regression analysis was conducted to determine the relationship between UA level and these indexes. Results The incidence rates of hypertension, hypercholesterolemia, hypertriglyceridemia, low HDL, and high LDL were significantly higher in hyperuricemia group than in normal UA group (P<0.01). The Multiple logistc-regression analysis suggested that high UA level was closely related to TG (OR=1.637, P<0.01), DBP (OR=1.025, P<0.01) and body weight (OR=1.046, P<0.01). Conclusion The serum UA of pilots is closely related to the risk factors of other cardiovascular diseases.