Trienomycin J, a new ansamycin from deep-sea derived bacterium Ochrobactrum sp / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 5661-5665, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-850655
ABSTRACT
Objective:
To identify the cytotoxic natural products from the deep-sea derived Ochrobactrum sp. OUCMDZ-2164.Methods:
The isolations and purifications of compounds were performed by means of column chromatography over silica gel and Sephadex LH-20 as well as HPLC. Their structures were elucidated through the analysis of UV, IR, MS, NMR and ECD spectra. The cytotoxicities against MCF-7, A549 and K562 cells were evaluated by MTT and CCK-8 methods.Results:
From the fermentation broth of Ochrobactrum sp. OUCMDZ-2164, we isolated and identified four compounds (1-4). Compound 1 was identified as a new ansamycin and named trienomycin J, and the structures of 1-4 were identified as 3-O-demethyltrienomycinol, flazin, flazin-3- carboxylic acid and thymine, respectively. Compound 1 showed cytotoxic effect on the MCF-7 cells with 61.5% inhibition rate at 10 μmol/L.Conclusion:
Compound 1 was a new ansamycin named trienomycin J, with cytotoxic activity against human breast cancer cells (MCF-7).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2019
Tipo de documento:
Artigo
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