Box-Behnken response surface method optimized technological research of ultrafiltration-complexation extraction and back extraction technology to prepare liquiritigenin / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 5739-5744, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-850666
ABSTRACT
Objective:
A technological route was established for preparing liquiritigenin from the licorice ultrafiltrate.Methods:
U5(53) uniform design was used to optimize the ultrafiltration process with the retention rate of liquiritigenin as the index; Box-Behnken response surface method was used to optimize the complexation extraction process with the extraction rate of liquiritigenin as the index; The technological condition of back extraction of liquiritigenin was determined by the liquiritigenin stripping rate.Results:
The optimal ultrafiltration conditions for liquiritigenin were inorganic ceramic membranes with a pore size of 10 nm, a pressure of 0.12 MPa, and solution temperature of 25 ℃, retention rate of liquiritigenin was 98.74%. Optimum complexation extraction conditions were as following 1% TRPO complexing agent, extraction for 10 min in 5 mL organic phase solution, the extraction rate of liquiritigenin was 99.44%; The 12.5 mmol/L NaOH aqueous solution was the best back-extractant, and the back extraction rate was 98.88%.Conclusion:
As a new Chinese medicine extraction technology, ultrafiltration-complexation extraction and back extraction technology have the advantages of high selectivity, high efficiency, and recycling of extractant, which can provide a new preparation technology for the research of liquiritigenin.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2019
Tipo de documento:
Artigo
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