Study on chemical constituents of Ligularia veitchiana / 中草药

ABSTRACT

Objective: To study the chemical constituents of the aerial parts of Ligularia veitchiana. Methods: The isolation and purification were carried out by macroporous resin, silica gel column chromatography, Sephadex LH-20, and semi-preparative HPLC. Their structures were elucidated on the basis of physicochemical properties and spectroscopic data. Results: A total of 16 compounds were isolated and elucidated from the aerial parts of Ligularia veitchiana, their structures were identified as: 2-hydroxplatyphyllide (1), ligudentatin A (2), 2-metyoxy-platyphillide (3), 7-hydroxy-11-hydroperoxybisabol-2,9E-diene (4), bisabola-2,11-diene-7α,10ζ-diol (5), 8β,10β-dihydroxyeremophilenolide (6), 3β(ax)-hydroxyeremophillenolide (7), 6β-hydroxy- 8α-ethoxyeremophil-7(11)-en-12,8β-olide (8), 3β,28-dibydroxylup-20(29)-ene (9), oleanolic acid (10), 3β-hydroxyolean-12-en-27- oic acid (11), ursolic acid (12), coniferyl ferulate (13), 4-O-Geranyl-sinapyl alcohol (14), 4-O-geranyl-coniferyl alcohol (15), auraptene (16). Conclusion: All compounds are isolated from Ligularia veitchiana for the first time. Compounds 4, 5, 7, 8, 11 are isolated from the genus Ligularia for the first time.