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Preparation and Biodistribution of Re-188-Sulfur Colloid Suspension in Lipiodol / 대한핵의학회잡지
Korean Journal of Nuclear Medicine ; : 301-307, 2003.
Artigo em Coreano | WPRIM | ID: wpr-85078
ABSTRACT

PURPOSE:

Lipiodol is used for targeting liver cancers by administrating through the hepatic artery. In the present study, feasibility of Re-188-sulfur colloid suspension in lipiodol as a liver cancer targeting agent was investigated. MATERIALS AND

METHODS:

Re-188-sulfur colloid was prepared, harvested by centrifugation, washed with organic solvent and then suspended into lipiodol. Biodistribution of Re-188-sulfur colloid in normal saline and its suspension in lipiodol in mice after 1 hr of injection through the tail vein were investigated. Biodistribution and autoradiography of tumor-bearing liver was acquired after 5 min post-injection into left ventricle of the tumor-inoculated rats.

RESULTS:

After 1 hr of injection with Re-188-sulfur colloid suspensiob in lipiodol through the tail vein in normal mice (n=3), the uptakes in the liver and lung were 5.2+/-0.7 and 91.0+/-1.7% ID/organ, respectively. After 5 min of injection with Re-188-sulfur colloid suspention in lipiodol through the left ventricle in the tumor-inoculated rats (n=4), uptakes in the normal liver, hepatoma, and lung were 0.41+/-0.28, 1.88+/-1.57, and 1.65+/-1.54% ID/organ, respectively. And autoradiography of hepatoma showed increased uptake than normal liver tissues.

CONCLUSION:

Re-188-sulfur colloid suspension in lipiodol injected through the artery shows higher uptake in the hepatoma than normal liver tissue that indicates the feasibility as a new radiopharmaceutical for therapy of hepatoma.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artérias / Autorradiografia / Veias / Centrifugação / Estudos de Viabilidade / Coloides / Óleo Etiodado / Carcinoma Hepatocelular / Ventrículos do Coração / Artéria Hepática Limite: Animais Idioma: Coreano Revista: Korean Journal of Nuclear Medicine Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artérias / Autorradiografia / Veias / Centrifugação / Estudos de Viabilidade / Coloides / Óleo Etiodado / Carcinoma Hepatocelular / Ventrículos do Coração / Artéria Hepática Limite: Animais Idioma: Coreano Revista: Korean Journal of Nuclear Medicine Ano de publicação: 2003 Tipo de documento: Artigo