Novel control model of quality marker of Chinese materia medica based on supramolecular “imprinted template” characteristics / 中草药

ABSTRACT

The safety and effectiveness of Chinese materia medica (CMM) depend on its quality, and the modernization of CMM quality control system is an important prerequisite for the internationalization of traditional Chinese medicine (TCM). Up to now, the quality research approach of CMM is the key technology for TCM industry. In recent years, with the development of modern life science, chemistry science, analytical science and technology, the quality research level of CMM has been greatly improved, but it still stays on the two evaluation models based on chemical composition and biological effect. For single compound, because the effect is proportional to the content of components, the chemical composition can be used for quality control. However, for multi-component system of CMM, how to establish the dose-effect relationship between effects and components and find the markers reflecting their quality has become the focus of the quality control of CMM for TCM industry. Based on the theory of supramolecular “imprinting template” and “Qi-xi” put forward earlier, this paper first analyzed the characteristics of supramolecular “imprinting template” for the quality of CMM, clarified the essence of quality control of CMM, and proposed the attributes of supramolecular “imprinting template” to reflect the main effect of CMM. The control strategy of quality markers of CMM represented by core index will provide a new and more accurate characterization and calculation model for quality control of CMM.