Analysis of quality marker in Naozhenning Granule based on “five principles” / 中草药

ABSTRACT

Naozhenning Granule (NG) is a traditional Chinese medicine prescription, which can cool and activate blood, resolve stasis and dredge collaterals, enrich blood and tranquilize mind, calm nerves and arrest vomiting. The clinical studies have also confirmed that NG was effective for the treatment of headache, dizziness, irritability, insomnia, forgetfulness, nausea, and vomiting caused by cerebral trauma. The quality markers (Q-markers) of NG are predicted and analyzed based on the “five principles” of Q-markers of Chinese materia medica and the research literatures in the recent years. The modern pharmacological research of the selected Q-markers was reviewed and analyzed. Then the network of “Q-marker, targets, pathway, and disease” was constructed, in order to provide the scientific basis for the quality control study of NG.