Research progress on depression and mechanism of anti-depressant Chinese materia medica based on PI3K/Akt signaling pathway / 中草药

ABSTRACT

The phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) signaling pathway is one of the important signaling pathways for regulating cell survival, differentiation and apoptosis in vivo, which plays an important role in the occurrence of cancer, diabetes, nervous system diseases and the mechanisms of related drugs. In recent years, attention has been paid to the role of PI3K/Akt signaling pathway in the study of depression and the mechanism of antidepressant traditional Chinese medicine. This article reviews the relationship between key targets of PI3K/Akt signaling pathway and depression, the role of PI3K/Akt signaling pathway in depression and PI3K/Akt signaling pathway in the study of mechanism of antidepressant traditional Chinese medicine, which provides a reference for the treatment of depression and the discovery of antidepressant drugs.