Consideration on cardiotoxicity and clinical safety evaluation method of Chinese materia medica / 中草药

ABSTRACT

Traditional Chinese medicine has developed for thousands of years, and its clinical application has unique advantages. It is generally believed that Chinese medicine (CM) has few toxic and side effects and it is safe. However, in recent years, more and more clinical cases and basic research reports about hepatotoxicity, nephrotoxicity, and cardiotoxicity of CM have been reported. Therefore, we also increasingly concerned about the toxicity of Chinese materia medica (CMM). Cardiotoxicity assessment is an important index that must be considered before clinical trials of drugs. It also plays an important role in the research and development of new Chinese medicines and the standardized application of clinical safety of CM. Then, how to identify the cardiotoxicity of CMM, grasp the clinical characteristics, detection indicators, evaluation methods, and diagnostic elements are the main problems we are facing. In this paper, we summarized many researches and pre-clinical evaluation techniques of cardiotoxicity of CMM in recent years, and discussed and considered the clinical evaluation methods of cardiotoxicity of CMM.