Research progress on regulation mechanism of tanshinone IIA on cell apoptosis and autophagy in ischemic heart diseases / 中草药

ABSTRACT

Ischemic heart disease is a leading cause of morbidity and mortality throughout the world which is a serious threat to human health. Tanshinone IIA is a major lipophilic component extracted from the roots of Salvia miltiorrhiza. Studies have shown that tanshinone IIA has a variety of anti-cardiovascular diseases, and its mechanism is related to the regulation of myocardial cell apoptosis and autophagy. This article discusses the signaling pathways and their correlations related to apoptosis and autophagy in ischemic heart disease. The recent advances about the regulation of apoptosis and autophagy in the treatment to ischemia heart disease by tanshinong IIA were summarized. The mechanism of regulating apoptosis and autophagy to produce cardiovascular protection was discussed. This paper will provide a basis for in-depth study of ischemic heart disease and the development and utilization of drugs.