Construction of inorganic elemental fingerprint and principal component analysis of Guilingji Capsule / 中草药

ABSTRACT

Objective: To establish the inorganic elemental fingerprint of Guilingji Capsule and evaluate the uniformity of the product quality, and explore the characteristic elements in Guilingji Capsule. Methods: The levels of 14 inorganic elements in 10 different production batches of Guilingji Capsule were determined by ICP-MS with microwave digestion for sample preparation. The content distribution curve of inorganic elements was plotted, and the principal component analysis (PCA) were analyzed with the IBM SPSS Statistics 22.0. Results: Forteen kinds of inorganic elements were selected to establish fingerprint for describing and identifying the quality of Guilingji Capsule. The similarity (angle cosine value) were all more than 0. 970. Four main factors were selected by PCA. The PCA results showed that Cr, Mn, Fe, Zn, and Se might be the characteristic elements in Guilingji Capsule. Conclusion: The inorganic elemental fingerprint of Guilingji Capsule can provide the research basis for quality control.