Three new cucurbitane-type triterpenoid saponins from tubers of Hemsleya pengxianensis var. jinfushanensis / 中草药

ABSTRACT

Objective: To study the chemical constituents of the tubers of Hemsleya pengxianensis var. jinfushanensis. Methods: The compounds of the ethyl acetate fraction were isolated by silica gel, ODS reversed phase column chromatography, and preparative high-performance liquid chromatography (prep-HPLC). The structures of these compounds were identified by IR, HRESIMS, and NMR spectra. Results: Three new compounds were obtained from the ethyl acetate fraction of the tubers of H. pengxianensis var. jinfushanensis and identified as 3β,26-dihydroxy-cucurbita-5,24(E)-diene-7,11-dione-3-O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranoside (1), 3β,11α,26-trihydroxy-cucurbita-5,24(E)-diene-3-O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl (1→6)-α-L-arabinoside (2), and 3β,27-dihydroxy-cucurbita-5,24(Z)-diene-3-O-β-D-glucopyranosyl-27-O-β-D-glucopyranosyl (1→6)- β-D-glucopyranoside (3). Conclusion: Compounds 1-3 are new compounds named hemslepenside Q, hemslepenside R, and hemslepenside S, respectively.